DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification

Glioblastomas (GBM) are highly radioresistant and lethal brain tumors. Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are a risk factor for the development of GBM. In this study, we systematically examined the contribution of IR-induced DSBs to GBM development using transgenic mouse...

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Bibliografiset tiedot
Päätekijät: Camacho, Cristel V., Todorova, Pavlina K., Gillam, Molly C., Tomimatsu, Nozomi, del Alcazar, Carlos R Gil, Ilcheva, Mariya, Mukherjee, Bipasha, McEllin, Brian, Vemireddy, Vamsidhara, Hatanpaa, Kimmo, Story, Michael D., Habib, Amyn A., Murty, Vundavalli V., Bachoo, Robert, Burma, Sandeep
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167163/
https://ncbi.nlm.nih.gov/pubmed/24632607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.29
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