Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas

Glioblastomas (GBM) are lethal brain tumors which are treated with conventional radiation (X-rays and gamma rays) or particle radiation (protons and carbon ions). Paradoxically, radiation is also a risk factor for GBM development, raising the possibility that radiotherapy of brain tumors could promo...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Todorova, Pavlina K., Fletcher-Sananikone, Eliot, Mukherjee, Bipasha, Kollipara, Rahul, Vemireddy, Vamsidhara, Xie, Xian-Jin, Guida, Peter M., Story, Michael D., Hatanpaa, Kimmo, Habib, Amyn A., Kittler, Ralf, Bachoo, Robert, Hromas, Robert, Floyd, John R., Burma, Sandeep
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635038/
https://ncbi.nlm.nih.gov/pubmed/31088835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0680
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