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Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator

Since the discovery of the cystic fibrosis (CF) gene that encodes the CF transmembrane conductance regulator (CFTR) in 1989, there has been considerable progress in understanding the molecular defects associated with different mutations in the CFTR protein. Small molecule “potentiators” have led the...

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Main Authors: Collawn, James F., Fu, Lianwu, Bartoszewski, Rafal, Matalon, Sadis
格式: Artigo
語言:Inglês
出版: American Physiological Society 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166784/
https://ncbi.nlm.nih.gov/pubmed/25063802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00177.2014
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