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Activation of the Unfolded Protein Response by ΔF508 CFTR

Environmental insults and misfolded proteins cause endoplasmic reticulum (ER) stress and activate the unfolded protein response (UPR). The UPR decreases endogenous cystic fibrosis transmembrane conductance regulator (CFTR) mRNA levels and protein maturation efficiency. Herein, we investigated the ef...

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Bibliografiske detaljer
Main Authors: Bartoszewski, Rafal, Rab, Andras, Jurkuvenaite, Asta, Mazur, Marina, Wakefield, John, Collawn, James F., Bebők, Zsuzsa
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551705/
https://ncbi.nlm.nih.gov/pubmed/18458236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0065OC
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