A Synonymous Single Nucleotide Polymorphism in ΔF508 CFTR Alters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

Recent advances in our understanding of translational dynamics indicate that codon usage and mRNA secondary structure influence translation and protein folding. The most frequent cause of cystic fibrosis (CF) is the deletion of three nucleotides (CTT) from the cystic fibrosis transmembrane conductan...

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Detalhes bibliográficos
Principais autores: Bartoszewski, Rafal A., Jablonsky, Michael, Bartoszewska, Sylwia, Stevenson, Lauren, Dai, Qun, Kappes, John, Collawn, James F., Bebok, Zsuzsa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937902/
https://ncbi.nlm.nih.gov/pubmed/20628052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154575
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