Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator

Since the discovery of the cystic fibrosis (CF) gene that encodes the CF transmembrane conductance regulator (CFTR) in 1989, there has been considerable progress in understanding the molecular defects associated with different mutations in the CFTR protein. Small molecule “potentiators” have led the...

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Bibliographic Details
Main Authors: Collawn, James F., Fu, Lianwu, Bartoszewski, Rafal, Matalon, Sadis
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Editorial Focus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166784/
https://ncbi.nlm.nih.gov/pubmed/25063802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00177.2014
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