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Rescuing ΔF508 CFTR with trimethylangelicin, a dual-acting corrector and potentiator

Since the discovery of the cystic fibrosis (CF) gene that encodes the CF transmembrane conductance regulator (CFTR) in 1989, there has been considerable progress in understanding the molecular defects associated with different mutations in the CFTR protein. Small molecule “potentiators” have led the...

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Библиографические подробности
Главные авторы: Collawn, James F., Fu, Lianwu, Bartoszewski, Rafal, Matalon, Sadis
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166784/
https://ncbi.nlm.nih.gov/pubmed/25063802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00177.2014
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