Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes

Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mu...

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Autors principals: Yen, Shuo-Ting, Zhang, Min, Deng, Jian Min, Usman, Shireen J., Smith, Chad N., Parker-Thornburg, Jan, Swinton, Paul G., Martin, James F., Behringer, Richard R.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166609/
https://ncbi.nlm.nih.gov/pubmed/24984260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.06.017
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