Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes

Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mu...

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Main Authors: Yen, Shuo-Ting, Zhang, Min, Deng, Jian Min, Usman, Shireen J., Smith, Chad N., Parker-Thornburg, Jan, Swinton, Paul G., Martin, James F., Behringer, Richard R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166609/
https://ncbi.nlm.nih.gov/pubmed/24984260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.06.017
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