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Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2(−/−) mice

The suppressor of cytokine signalling (Socs2 (−/−))-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2 (−/−) bone phenotype and determine whether GH promotes bone mass via IGF1-dependent mechanisms. Despite no...

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Bibliografiske detaljer
Main Authors: Dobie, R, MacRae, V E, Huesa, C, van't Hof, R, Ahmed, S F, Farquharson, C
Format: Artigo
Sprog:Inglês
Udgivet: Bioscientifica Ltd 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166176/
https://ncbi.nlm.nih.gov/pubmed/25074853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-14-0292
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