GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation

Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) is a secreted member of the transforming growth factor beta (TGF-β) superfamily. Deletion of Gdf11 has been shown to result in a skeletal anterior–posterior patterning disorder. Here we s...

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Publicado en:Nat Commun
Autores principales: Liu, Weiqing, Zhou, Liyan, Zhou, Chenchen, Zhang, Shiwen, Jing, Junjun, Xie, Liang, Sun, Ningyuan, Duan, Xiaobo, Jing, Wei, Liang, Xing, Zhao, Hu, Ye, Ling, Chen, Qianming, Yuan, Quan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036163/
https://ncbi.nlm.nih.gov/pubmed/27653144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12794
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