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Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2(−/−) mice
The suppressor of cytokine signalling (Socs2 (−/−))-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2 (−/−) bone phenotype and determine whether GH promotes bone mass via IGF1-dependent mechanisms. Despite no...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Bioscientifica Ltd
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4166176/ https://ncbi.nlm.nih.gov/pubmed/25074853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-14-0292 |
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