Programmed death-1 expression on HIV-1-specific CD8(+) T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load

OBJECTIVES: Although CD8(+) T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inhibitory receptors, such as programmed death-1 (P...

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Main Authors: Kløverpris, Henrik N., McGregor, Reuben, McLaren, James E., Ladell, Kristin, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David A., Goulder, Philip
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2014
Fag:
Basic Science
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4166042/
https://ncbi.nlm.nih.gov/pubmed/24906112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000362
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