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Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide

Aggregation of Islet Amyloid Polypeptide (IAPP) has been implicated in the development of type II diabetes. Because IAPP is a highly amyloidogenic peptide, it has been suggested that the formation of IAPP amyloid fibers causes disruption of the cellular membrane and is responsible for the death of β...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brender, Jeffrey R., Lee, Edgar L., Cavitt, Marchello A., Gafni, Ari, Steel, Duncan G., Ramamoorthy, Ayyalusamy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163023/
https://ncbi.nlm.nih.gov/pubmed/18444645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710484d
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