Enhanced dissolution and stability of Tanshinone IIA base by solid dispersion system with nano-hydroxyapatite

BACKGROUND: Tanshinone IIA (TSIIA) exhibits a variety of cardiovascular effects; however, it has low solubility in water. The preparation of poorly soluble drugs for oral delivery is one of the greatest challenges in the field of formulation research. Among the approaches available, solid dispersion...

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Bibliografiske detaljer
Main Authors: Jiang, Yan-rong, Zhang, Zhen-hai, Huang, Sai-yan, Lu, Yan, Ma, Tian-tian, Jia, Xiao-bin
Format: Artigo
Sprog:Inglês
Udgivet: Medknow Publications & Media Pvt Ltd 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159928/
https://ncbi.nlm.nih.gov/pubmed/25210322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0973-1296.137375
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