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Structure-guided reprogramming of human cGAS dinucleotide linkage specificity
Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2′-5′ phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157622/ https://ncbi.nlm.nih.gov/pubmed/25131990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.028 |
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