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Conserved strategies for pathogen evasion of cGAS–STING immunity

The cyclic GMP–AMP synthase (cGAS)– Stimulator of Interferon Genes (STING) pathway of cytosolic DNA sensing allows mammalian cells to detect and respond to infection with diverse pathogens. Pathogens in turn encode numerous factors that inhibit nearly all steps of cGAS–STING signal transduction. Fro...

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Pubblicato in:Curr Opin Immunol
Autori principali: Eaglesham, James B, Kranzusch, Philip J
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Author(s). Published by Elsevier Ltd. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158794/
https://ncbi.nlm.nih.gov/pubmed/32339908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2020.04.002
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