Chargement en cours...
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signaling
Cytosolic DNA triggers innate immune responses through activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′3′ cGAMP(1–4). 2′3′ cGAMP is a potent inducer of immune signaling, but no intracellular nucleases are known to cleave 2′3′ cGAMP and preven...
Enregistré dans:
| Publié dans: | Nature |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640140/ https://ncbi.nlm.nih.gov/pubmed/30728498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0928-6 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|