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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signaling
Cytosolic DNA triggers innate immune responses through activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′3′ cGAMP(1–4). 2′3′ cGAMP is a potent inducer of immune signaling, but no intracellular nucleases are known to cleave 2′3′ cGAMP and preven...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6640140/ https://ncbi.nlm.nih.gov/pubmed/30728498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-0928-6 |
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