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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
In humans, the cGAS-STING immunity pathway signals in response to cytosolic DNA via 2′,3′ cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed 2′–5′ and 3′–5′ phosphodiester bonds. Prokaryotes also produce CDNs, but these are exclusively 3′ linked, and thus the evolutionary origins o...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575873/ https://ncbi.nlm.nih.gov/pubmed/26300263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.022 |
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