Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

In humans, the cGAS-STING immunity pathway signals in response to cytosolic DNA via 2′,3′ cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed 2′–5′ and 3′–5′ phosphodiester bonds. Prokaryotes also produce CDNs, but these are exclusively 3′ linked, and thus the evolutionary origins o...

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Bibliographic Details
Published in:	Mol Cell
Main Authors:	Kranzusch, Philip J., Wilson, Stephen C., Lee, Amy S.Y., Berger, James M., Doudna, Jennifer A., Vance, Russell E.
Format:	Artigo
Language:	Inglês
Published:	2015
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4575873/ https://ncbi.nlm.nih.gov/pubmed/26300263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.022
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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling

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