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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Detection of microbial DNA is an evolutionarily conserved mechanism that alerts the host immune system to mount a defense response to microbial infections. However, this detection mechanism also poses a challenge to the host as to how to distinguish foreign DNA from abundant self-DNA. Cyclic guanosi...
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| 出版年: | J Exp Med |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Rockefeller University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940270/ https://ncbi.nlm.nih.gov/pubmed/29622565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180139 |
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