Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2′-5′ phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Kranzusch, Philip J., Lee, Amy S.Y., Wilson, Stephen C., Solovykh, Mikhail S., Vance, Russell E., Berger, James M., Doudna, Jennifer A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157622/
https://ncbi.nlm.nih.gov/pubmed/25131990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.028
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller