लोड हो रहा है...
Structure-guided reprogramming of human cGAS dinucleotide linkage specificity
Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2′-5′ phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity...
में बचाया:
| मुख्य लेखकों: | , , , , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2014
|
| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157622/ https://ncbi.nlm.nih.gov/pubmed/25131990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.028 |
| टैग : |
टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!
|