Structure-guided reprogramming of human cGAS dinucleotide linkage specificity

Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2′-5′ phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Kranzusch, Philip J., Lee, Amy S.Y., Wilson, Stephen C., Solovykh, Mikhail S., Vance, Russell E., Berger, James M., Doudna, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157622/
https://ncbi.nlm.nih.gov/pubmed/25131990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.028
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki