Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Chemokines mediate diverse functions from organogenesis to mobilizing leucocytes, and are unusual agonists for class-A GPCRs (G-protein-coupled receptors) because of their large size and multi-domain structure. The current model for receptor activation, which involves interactions between chemokine...

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Autori principali: Joseph, Prem Raj B., Sawant, Kirti V., Isley, Angela, Pedroza, Mesias, Garofalo, Roberto P., Richardson, Ricardo M., Rajarathnam, Krishna
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157346/
https://ncbi.nlm.nih.gov/pubmed/24032673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130148
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