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Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation
Chemokines mediate diverse functions from organogenesis to mobilizing leucocytes, and are unusual agonists for class-A GPCRs (G-protein-coupled receptors) because of their large size and multi-domain structure. The current model for receptor activation, which involves interactions between chemokine...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4157346/ https://ncbi.nlm.nih.gov/pubmed/24032673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130148 |
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