Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking

Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 receptors. How CXCL8 monomer and dimer interactions...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Open Biol
Prif Awduron: Joseph, Prem Raj B., Sawant, Kirti V., Rajarathnam, Krishna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society 2017
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717344/
https://ncbi.nlm.nih.gov/pubmed/29118271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170168
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