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Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking

Chemokine CXCL8 plays a pivotal role in host immune response by recruiting neutrophils to the infection site. CXCL8 exists as monomers and dimers, and mediates recruitment by interacting with glycosaminoglycans (GAGs) and activating CXCR1 and CXCR2 receptors. How CXCL8 monomer and dimer interactions...

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Foilsithe in:Open Biol
Main Authors: Joseph, Prem Raj B., Sawant, Kirti V., Rajarathnam, Krishna
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Royal Society 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717344/
https://ncbi.nlm.nih.gov/pubmed/29118271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170168
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