Role of TGFβ signaling in generation of CD39(+)CD73(+) myeloid cells in tumors

There is growing evidence that generation of adenosine from ATP, which is mediated by the CD39/CD73 enzyme pair, predetermines immunosuppressive and pro-angiogenic properties of myeloid cells. We have previously shown that the deletion of the TGFβ type II receptor gene (Tgfbr2) expression in myeloid...

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Autori principali: Ryzhov, Sergey V., Pickup, Michael W., Chytil, Anna, Gorska, Agnieszka E., Zhang, Qinkun, Owens, Philip, Feoktistov, Igor, Moses, Harold L., Novitskiy, Sergey V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157098/
https://ncbi.nlm.nih.gov/pubmed/25127858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400578
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