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Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties

By crossing LysM-Cre and TGF-β type II receptor (Tgfbr2) floxed mice we achieved specific deletion of Tgfbr2 in myeloid cells (Tgfbr2(MyeKO) mice). S.c.-injected (LLC, EL4-OVA) and implanted (MMTV-PyMT) carcinoma cells grow slower in Tgfbr2(MyeKO) mice. The number of CD45(+) cells in the tumor tissu...

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Autori principali: Novitskiy, Sergey V., Pickup, Michael W., Chytil, Anna, Polosukhina, Dina, Owens, Philip, Moses, Harold L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Leukocyte Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427612/
https://ncbi.nlm.nih.gov/pubmed/22685318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1211639
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