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Deletion of TGF-β signaling in myeloid cells enhances their anti-tumorigenic properties
By crossing LysM-Cre and TGF-β type II receptor (Tgfbr2) floxed mice we achieved specific deletion of Tgfbr2 in myeloid cells (Tgfbr2(MyeKO) mice). S.c.-injected (LLC, EL4-OVA) and implanted (MMTV-PyMT) carcinoma cells grow slower in Tgfbr2(MyeKO) mice. The number of CD45(+) cells in the tumor tissu...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Leukocyte Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427612/ https://ncbi.nlm.nih.gov/pubmed/22685318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1211639 |
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