TGF-β Receptor II Loss Promotes Mammary Carcinoma Progression by Th17 Dependent Mechanisms

We report that IL-17 significantly increases the secretion of CXCL1 and CXCL5 from mammary carcinoma cells, which is downregulated by TGF-β through the type II TGF-β receptor (TβRII). Carcinoma cells with conditional knockout of TβRII (Tgfbr2(KO)) have enhanced sensitivity to IL-17a in the stimulati...

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Detaylı Bibliyografya
Asıl Yazarlar: Novitskiy, Sergey V., Pickup, Michael W., Gorska, Agnieszka E., Owens, Philip, Chytil, Anna, Aakre, Mary, Wu, Huiyun, Shyr, Yu, Moses, Harold L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297196/
https://ncbi.nlm.nih.gov/pubmed/22408746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0100
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