Genetic and pharmacological reactivation of the mammalian inactive X chromosome

X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) fr...

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Bibliographic Details
Main Authors:	Bhatnagar, Sanchita, Zhu, Xiaochun, Ou, Jianhong, Lin, Ling, Chamberlain, Lynn, Zhu, Lihua J., Wajapeyee, Narendra, Green, Michael R.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2014
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4156765/ https://ncbi.nlm.nih.gov/pubmed/25136103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413620111
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Genetic and pharmacological reactivation of the mammalian inactive X chromosome

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