TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein

The TRIM37 (or MUL) gene is located in the 17q23 chromosomal region, which is amplified in up to ~40% of breast cancers(1). TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases(2), but its protein substrate(s) is unknown. Here we report that TRIM37 mono-ubiquitinates histone H2A,...

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Veröffentlicht in:Nature
Hauptverfasser: Bhatnagar, Sanchita, Gazin, Claude, Chamberlain, Lynn, Ou, Jianhong, Zhu, Xiaochun, Tushir, Jogender S., Virbasius, Ching-Man, Lin, Ling, Zhu, Lihua J., Wajapeyee, Narendra, Green, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269325/
https://ncbi.nlm.nih.gov/pubmed/25470042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13955
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