Genetic and pharmacological reactivation of the mammalian inactive X chromosome

X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) fr...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bhatnagar, Sanchita, Zhu, Xiaochun, Ou, Jianhong, Lin, Ling, Chamberlain, Lynn, Zhu, Lihua J., Wajapeyee, Narendra, Green, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156765/
https://ncbi.nlm.nih.gov/pubmed/25136103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413620111
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi