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Genetic and pharmacological reactivation of the mammalian inactive X chromosome
X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) fr...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4156765/ https://ncbi.nlm.nih.gov/pubmed/25136103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413620111 |
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