Genetic and pharmacological reactivation of the mammalian inactive X chromosome

X-chromosome inactivation (XCI), the random transcriptional silencing of one X chromosome in somatic cells of female mammals, is a mechanism that ensures equal expression of X-linked genes in both sexes. XCI is initiated in cis by the noncoding Xist RNA, which coats the inactive X chromosome (Xi) fr...

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Detalhes bibliográficos
Main Authors: Bhatnagar, Sanchita, Zhu, Xiaochun, Ou, Jianhong, Lin, Ling, Chamberlain, Lynn, Zhu, Lihua J., Wajapeyee, Narendra, Green, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156765/
https://ncbi.nlm.nih.gov/pubmed/25136103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413620111
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