Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice

Rett syndrome (RTT) is a genetic disorder resulting from a loss-of-function mutation in one copy of the X-linked gene methyl-CpG–binding protein 2 (MECP2). Typical RTT patients are females and, due to random X chromosome inactivation (XCI), ∼50% of cells express mutant MECP2 and the other ∼50% expre...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Przanowski, Piotr, Wasko, Urszula, Zheng, Zeming, Yu, Jun, Sherman, Robyn, Zhu, Lihua Julie, McConnell, Michael J., Tushir-Singh, Jogender, Green, Michael R., Bhatnagar, Sanchita
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077728/
https://ncbi.nlm.nih.gov/pubmed/30012595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803792115
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