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TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB

Toll-like receptor 2 (TLR2) is the best-characterized pattern-recognition receptor for the highly pathogenic intracellular bacterium, Francisella tularensis. We previously identified a mutant in the live vaccine strain (LVS) of Francisella, LVS clpB, which is attenuated, but induces a protective imm...

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Detalhes bibliográficos
Main Authors: Roberts, Lydia M., Ledvina, Hannah E., Sempowski, Gregory D., Frelinger, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155801/
https://ncbi.nlm.nih.gov/pubmed/25250027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00426
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