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Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell–mediated autoimmunity
Toll-like receptor 7 (Tlr7) has been linked to systemic lupus disease incidence in humans and mice, but how TLR7 potentiates autoimmunity is unclear. We used a Tlr7 transgenic (tg) mouse model to investigate the cellular and molecular events required to induce spontaneous autoimmunity through increa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479588/ https://ncbi.nlm.nih.gov/pubmed/22988104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209372109 |
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