Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models

Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. The importance of galectin-9 (Gal-9) in regulating v...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Panda, Santosh K., Facchinetti, Valeria, Voynova, Elisaveta, Hanabuchi, Shino, Karnell, Jodi L., Hanna, Richard N., Kolbeck, Roland, Sanjuan, Miguel A., Ettinger, Rachel, Liu, Yong-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919878/
https://ncbi.nlm.nih.gov/pubmed/29611821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97333
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados