Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models

Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. The importance of galectin-9 (Gal-9) in regulating v...

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Vydáno v:J Clin Invest
Hlavní autoři: Panda, Santosh K., Facchinetti, Valeria, Voynova, Elisaveta, Hanabuchi, Shino, Karnell, Jodi L., Hanna, Richard N., Kolbeck, Roland, Sanjuan, Miguel A., Ettinger, Rachel, Liu, Yong-Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919878/
https://ncbi.nlm.nih.gov/pubmed/29611821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97333
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