Control of TLR7 expression is essential to restrict autoimmunity and dendritic cell expansion

Nucleic acid-binding innate immune receptors such as TLR7 and TLR9 have been implicated in the development of some autoimmune pathologies. The Y chromosome-linked genomic modifier Yaa, which correlates with a duplication of TLR7 and 16 other genes, exacerbates lupus-like syndromes in several mouse s...

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Main Authors: Deane, Jonathan A., Pisitkun, Prapaporn, Barrett, Rebecca S., Feigenbaum, Lionel, Town, Terrence, Ward, Jerrold M., Flavell, Richard A., Bolland, Silvia
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706502/
https://ncbi.nlm.nih.gov/pubmed/17997333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.09.009
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