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Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance and accelerated autoimmunity
Type I interferons (IFN-I) are normally produced during antiviral responses, yet high levels of chronic IFN-I expression correlate with autoimmune disease. A variety of viral sensors generate IFN-I in their response, but other than TLRs it is not fully known which pathways are directly involved in t...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262963/ https://ncbi.nlm.nih.gov/pubmed/22205024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102705 |
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