Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN-α and Serologic Autoimmunity in Lupus Patients

Increased IFN-α signaling is a heritable risk factor for systemic lupus erythematosus (SLE). IFN induced with helicase C domain 1 (IFIH1) is a cytoplasmic dsRNA sensor that activates IFN-α pathway signaling. We studied the impact of the autoimmune-disease–associated IFIH1 rs1990760 (A946T) single nu...

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Detalhes bibliográficos
Main Authors: Robinson, Talin, Kariuki, Silvia N., Franek, Beverly S., Kumabe, Marissa, Kumar, Akaash A., Badaracco, Maria, Mikolaitis, Rachel A., Guerrero, Galen, Utset, Tammy O., Drevlow, Barbara E., Zaacks, Laura S., Grober, James S., Cohen, Lewis M., Kirou, Kyriakos A., Crow, Mary K., Jolly, Meenakshi, Niewold, Timothy B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304466/
https://ncbi.nlm.nih.gov/pubmed/21705624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100857
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