Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation

Endosomal toll-like receptor (TLR)-mediated detection of viral nucleic acids (NAs) and production of type I interferon (IFN-I) are key elements of antiviral defense, while inappropriate recognition of self NAs with the induction of IFN-I responses is linked to autoimmunity such as psoriasis and syst...

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Pubblicato in:Sci Rep
Autori principali: Takagi, Hideaki, Arimura, Keiichi, Uto, Tomofumi, Fukaya, Tomohiro, Nakamura, Takeshi, Choijookhuu, Narantsog, Hishikawa, Yoshitaka, Sato, Katsuaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830934/
https://ncbi.nlm.nih.gov/pubmed/27075414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24477
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