Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell–mediated autoimmunity

Toll-like receptor 7 (Tlr7) has been linked to systemic lupus disease incidence in humans and mice, but how TLR7 potentiates autoimmunity is unclear. We used a Tlr7 transgenic (tg) mouse model to investigate the cellular and molecular events required to induce spontaneous autoimmunity through increa...

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Bibliografische gegevens
Hoofdauteurs: Walsh, Elizabeth R., Pisitkun, Prapaporn, Voynova, Elisaveta, Deane, Jonathan A., Scott, Bethany L., Caspi, Rachel R., Bolland, Silvia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479588/
https://ncbi.nlm.nih.gov/pubmed/22988104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209372109
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