Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2

Histone deacetylase 2 (HDAC2) is a chromatin modifier involved in epigenetic regulation of cell cycle, apoptosis and differentiation that is upregulated commonly in human hepatocellular carcinoma (HCC). In this study, we show that specific targeting of this HDAC isoform is sufficient to inhibit HCC...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Yun-Han, Seo, Daekwan, Choi, Kyung-Ju, Andersen, Jesper B., Won, Min-Ah, Kitade, Mitsuteru, Gómez-Quiroz, Luis E., Judge, Adam D., Marquardt, Jens U., Raggi, Chiara, Conner, Elizabeth A., MacLachlan, Ian, Factor, Valentina M., Thorgeirsson, Snorri S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155016/
https://ncbi.nlm.nih.gov/pubmed/24958469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3531
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