Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2

Histone deacetylase 2 (HDAC2) is a chromatin modifier involved in epigenetic regulation of cell cycle, apoptosis and differentiation that is upregulated commonly in human hepatocellular carcinoma (HCC). In this study, we show that specific targeting of this HDAC isoform is sufficient to inhibit HCC...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lee, Yun-Han, Seo, Daekwan, Choi, Kyung-Ju, Andersen, Jesper B., Won, Min-Ah, Kitade, Mitsuteru, Gómez-Quiroz, Luis E., Judge, Adam D., Marquardt, Jens U., Raggi, Chiara, Conner, Elizabeth A., MacLachlan, Ian, Factor, Valentina M., Thorgeirsson, Snorri S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155016/
https://ncbi.nlm.nih.gov/pubmed/24958469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3531
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky