Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2

Histone deacetylase 2 (HDAC2) is a chromatin modifier involved in epigenetic regulation of cell cycle, apoptosis and differentiation that is upregulated commonly in human hepatocellular carcinoma (HCC). In this study, we show that specific targeting of this HDAC isoform is sufficient to inhibit HCC...

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Autors principals: Lee, Yun-Han, Seo, Daekwan, Choi, Kyung-Ju, Andersen, Jesper B., Won, Min-Ah, Kitade, Mitsuteru, Gómez-Quiroz, Luis E., Judge, Adam D., Marquardt, Jens U., Raggi, Chiara, Conner, Elizabeth A., MacLachlan, Ian, Factor, Valentina M., Thorgeirsson, Snorri S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155016/
https://ncbi.nlm.nih.gov/pubmed/24958469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3531
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