NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis

The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism b...

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Autori principali: Weaver, Kelly L., Alves-Guerra, Marie-Clotilde, Jin, Ke, Wang, Zhiqiang, Han, Xiaoqing, Ranganathan, Prathibha, Zhu, Xiaoxia, DaSilva, Thiago, Liu, Wei, Ratti, Francesca, Demarest, Renee M., Tzimas, Cristos, Rice, Meghan, Vasquez-Del Carpio, Rodrigo, Dahmane, Nadia, Robbins, David J., Capobianco, Anthony J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154994/
https://ncbi.nlm.nih.gov/pubmed/25038227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1547
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