Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to ra...

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Bibliographische Detailangaben
Hauptverfasser: Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Macias, MiMi P, Kalback, Walter M, Sabbagh, Marwan N, Beach, Thomas G, Vassar, Robert, Roher, Alex E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Libertas Academica 2013
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154482/
https://ncbi.nlm.nih.gov/pubmed/25210460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCI.S13025
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