Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to ra...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Macias, MiMi P, Kalback, Walter M, Sabbagh, Marwan N, Beach, Thomas G, Vassar, Robert, Roher, Alex E
Format: Artigo
Langue:Inglês
Publié: Libertas Academica 2013
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154482/
https://ncbi.nlm.nih.gov/pubmed/25210460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCI.S13025
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires