Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to ra...

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Bibliografiset tiedot
Päätekijät: Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Macias, MiMi P, Kalback, Walter M, Sabbagh, Marwan N, Beach, Thomas G, Vassar, Robert, Roher, Alex E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Libertas Academica 2013
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Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154482/
https://ncbi.nlm.nih.gov/pubmed/25210460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCI.S13025
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