Molecular Differences and Similarities Between Alzheimer’s Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis

Transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three amyloid precursor protein (APP) mutations, was designed to ra...

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Detalhes bibliográficos
Main Authors: Maarouf, Chera L, Kokjohn, Tyler A, Whiteside, Charisse M, Macias, MiMi P, Kalback, Walter M, Sabbagh, Marwan N, Beach, Thomas G, Vassar, Robert, Roher, Alex E
Formato: Artigo
Idioma:Inglês
Publicado em: Libertas Academica 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154482/
https://ncbi.nlm.nih.gov/pubmed/25210460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/BCI.S13025
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